Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME) or ME/CFS, is a complex, chronic illness characterized by severe, persistent fatigue that doesn’t improve with rest and worsens with physical or mental activity. The exact cause is not fully understood, and there is no single definitive test for diagnosing CFS/ME. Diagnosis is often based on exclusion, meaning that other potential causes of the symptoms are ruled out.

Although there isn’t a specific blood test that can definitively diagnose CFS/ME, several blood tests are often ordered to rule out other conditions that might cause similar symptoms and to identify abnormalities that may support the diagnosis.

Common Blood Tests for Chronic Fatigue Syndrome Evaluation:

  • C-Reactive Protein (CRP)
  • Vitamin D Level
  • Lymphocyte Subsets (CD4/CD8)
  • Epstein-Barr Virus Antibody Profile

Additional Tests Based on Symptoms:

Depending on the patient’s symptoms, additional tests might be ordered, including:

  • Sleep studies: To rule out sleep apnea or other sleep disorders.
  • Adrenal function tests: To evaluate for adrenal insufficiency (e.g., Addison’s disease).
  • Infectious disease screening: For conditions like Lyme disease or HIV.
  • Cortisol levels: To assess adrenal gland function and rule out issues like Cushing’s syndrome or adrenal insufficiency.
  • Autoantibody profiles: If there are signs of autoimmune involvement.

Conclusion:

While there is no single blood test to diagnose Chronic Fatigue Syndrome (CFS/ME), a range of blood tests can help rule out other potential causes of fatigue, such as infections, autoimmune diseases, thyroid disorders, and nutritional deficiencies. After ruling out these other conditions, and based on the patient’s symptoms, healthcare providers may diagnose CFS/ME. This diagnosis is largely clinical and relies on meeting specific criteria, including the presence of persistent, unexplained fatigue lasting for at least six months and other associated symptoms like cognitive dysfunction and post-exertional malaise.

Results – 5 days from Laboratory receiving sample