The Alanine Aminotransferase (ALT) Blood Test, also known as SGPT (serum glutamic-pyruvic transaminase), measures the level of ALT enzyme in your blood. It is a key indicator of liver health and is used to diagnose and monitor liver conditions.

What Is ALT?

ALT is an enzyme primarily found in the liver. It plays a vital role in breaking down proteins into energy. When liver cells are damaged or inflamed, ALT leaks into the bloodstream, resulting in elevated levels.

Why Is the ALT Test Performed?

This test is commonly ordered to:

  • Detect and monitor liver diseases like hepatitis, fatty liver, or cirrhosis.
  • Evaluate the effects of medications that may impact liver function.
  • Investigate symptoms of potential liver issues.
  • Screen individuals with a higher risk of liver damage, such as those with alcohol use disorder, obesity, or diabetes.

Symptoms That May Lead to an Alanine Aminotransferase (SGPT) Blood Test

Your doctor may recommend this test if you experience:

  • Jaundice (yellowing of the skin or eyes)
  • Persistent fatigue or weakness
  • Abdominal pain or swelling
  • Dark urine or pale stool
  • Nausea or vomiting

How Is the Test Conducted?

  1. Sample Collection: A blood sample is drawn from a vein in your arm.
  2. Lab Analysis: The sample is tested to measure ALT levels.
  3. Results Interpretation:
    • Normal Range: Typically 7–56 units per liter (U/L), though this can vary by lab.
    • Elevated Levels: May indicate liver inflammation or damage.

Common Conditions Linked to Abnormal ALT Levels

  • Elevated ALT Levels: Associated with liver conditions such as hepatitis, fatty liver disease, cirrhosis, or liver tumors.
  • Low ALT Levels: Rarely significant but may be linked to overall poor liver function or malnutrition.

Preparation and Risks

  • Preparation: No special preparation is needed, but you may be asked to avoid certain medications or foods that can affect ALT levels.
  • Risks: The blood draw involves minimal risks, such as slight discomfort or bruising.

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