The Double-Stranded DNA Antibodies (dsDNA) Blood Test is a critical diagnostic tool for identifying autoimmune conditions, particularly Systemic Lupus Erythematosus (SLE). This highly specific test measures the presence of antibodies that target the body’s own DNA, helping confirm diagnoses and monitor disease progression.

What Is the dsDNA Blood Test?

The dsDNA blood test detects autoantibodies against double-stranded DNA, which are commonly associated with lupus and other autoimmune disorders. These antibodies indicate an immune system dysfunction where the body mistakenly attacks its own genetic material.

Why Is the dsDNA Test Performed?

Your doctor may recommend this test if you are experiencing symptoms suggestive of lupus or other autoimmune diseases, such as:

  • Persistent fatigue
  • Joint pain or swelling
  • Butterfly-shaped rash on the face
  • Sensitivity to sunlight
  • Unexplained fever
  • Hair loss
  • Kidney issues (e.g., blood or protein in urine)

The dsDNA test is also used to:

  • Confirm a lupus diagnosis after a positive antinuclear antibody (ANA) test.
  • Monitor lupus disease activity, especially when kidney involvement is suspected.

How Is the dsDNA Test Conducted?

  1. Blood Sample Collection:
    • A healthcare provider draws a small blood sample from a vein in your arm.
  2. Laboratory Analysis:
    • The sample is tested to identify and measure dsDNA antibody levels.
    • Techniques such as ELISA or indirect immunofluorescence may be used.
  3. Results Interpretation:
    • Positive Test: Suggests active lupus or related autoimmune activity.
    • Negative Test: Indicates the absence of dsDNA antibodies, but does not rule out lupus entirely.

Understanding Test Results

  • High Levels of dsDNA Antibodies: Strongly associated with lupus and may correlate with disease severity, especially kidney involvement (lupus nephritis).
  • Low or Undetectable Levels: May occur in mild lupus or when the disease is in remission.

Preparation and Risks

  • Preparation: No special preparation is required for this test. Inform your doctor about any medications or supplements you are taking.
  • Risks: Minimal risks include mild discomfort or bruising at the blood draw site.

To book please use the link below or call our friendly team on 01443 303003.

Back to Blood Tests